Welcome to the Parrott Laboratory
Currently, our research is focused on rapidly screening and identifying cancer imaging agents using Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT). Specifically, polymers, proteins and nanoparticles are being evaluated as potential imaging agents. My laboratory is most interested in the evaluation of antibodies that target cell-surface receptors on tumors including EGFR, CD44, and PD-L1. A major limitation of antibody therapy is the need for tissue biopsies to measure the tumor – antibody interaction. I address this limitation by developing in vivo imaging agents that non-invasively monitors tracer migration and tumor accumulation. My group uses state-of-the-art equipment found in radiology and nuclear medicine to assess the pharmacokinetics of each material. Specifically, radioactive tracers are tracked using scintillation counting, Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT). I use nuclear chemistry, in vitro based assays, and in vivo imaging to identify new imaging agents with low background signal, minimal non-target tissue uptake, and enhanced tumor accumulation.